Transforming Growth Factor Beta1 Expression in Cancer- Associated Fibroblasts of Urinary Bladder Cancer: Crucial Applications and Deep Insights

Background: Urinary bladder carcinoma (UBC) is one of the most common malignancies in Egypt and all over world. TGFB levels plasma urine were proved to connote predictive prognostic attributes UBC patients. Furthermore, Cancer associated fibroblasts (CAFs) are now recognized as a key player carcinogenesis. Yet, TGFΒ1 expression CAFs had not been elucidated. Moreover, TGFB1 targeted therapy emerging with potential benefits for expressing cancers.
 Aim study: we dedicated this study explore implications immunohistochemical by correlating it relevant clinical pathological data.
 Material methods: This retrospective included 48 specimens. Different tumor grades presented balanced groups. was evaluated, categorized low or high compared among different grades, statistical analysis results then followed.
 Results: significantly histologic types (P=0.01), grade (P=<0.01), presence muscle invasion (P=<0.001), higher stage preceding bilharziasis (P=0.003), necrosis (P=0.03). There highly significant difference between both cells (P=0.002). Intense staining also strikingly observed along invading frontside further emphasizing pivotal role invasion.
 Conclusion: demonstrates UBC, thus its management therapy.